To see if that’s the problem for you, try running the game as an administrator to give it high integrity access. If you’re running Crusader Kings 2 on a standard user account, the game might not be able to access all the game files and folders.
If your problem still exists after the reboot, move on to the next fix below. If you have either of the two programs on your PC, please turn the program off during gameplay. Many players manage to fix the Crusader Kings 2 launching issue by turning off Nvidia Geforce Experience and EVGA Precision X.